Difelikefalin
Difelikefalin (pronounced di-fe-li-ke-fa-lin) is a medical term referring to a synthetic peptide drug that is used for the treatment of moderate to severe pruritus (itching) in hemodialysis patients. It is a peripherally restricted kappa opioid receptor (KOR) agonist.
Etymology
The term "Difelikefalin" is derived from the scientific nomenclature of the drug. The prefix "Di-" refers to the two phenylalanine (F) residues in the molecule, "-like-" refers to its similarity to endogenous opioids, and "-falin" is a common suffix for synthetic peptides.
Pharmacology
Difelikefalin is a selective kappa opioid receptor agonist. It works by binding to the kappa opioid receptors in the peripheral nervous system, which are involved in the sensation of itch. By activating these receptors, Difelikefalin can reduce the sensation of itch in patients undergoing hemodialysis.
Clinical Use
Difelikefalin is used for the treatment of moderate to severe pruritus in adult patients undergoing hemodialysis. Pruritus, or itching, is a common side effect of hemodialysis, and Difelikefalin has been shown to significantly reduce this symptom in clinical trials.
Related Terms
- Pruritus: A sensation that causes the desire or reflex to scratch.
- Hemodialysis: A process of purifying the blood of a person whose kidneys are not working normally.
- Kappa Opioid Receptor: A type of opioid receptor that is involved in the sensation of pain and itch.
See Also
External links
- Medical encyclopedia article on Difelikefalin
- Wikipedia's article - Difelikefalin
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