Dilute Russell's viper venom time
Dilute Russell's Viper Venom Time (dRVVT) is a laboratory test used to investigate the clotting time of blood, particularly in the context of diagnosing lupus anticoagulant (LA), an autoimmune disorder. This test is crucial in the field of hematology, as it helps in identifying the presence of antiphospholipid antibodies, which are associated with an increased risk of blood clots, miscarriage, and other complications.
Overview
The dRVVT test works by adding a small amount of venom from the Russell's viper to the patient's plasma. Russell's viper venom directly activates Factor X to Factor Xa, bypassing the need for phospholipids and certain clotting factors. In the presence of lupus anticoagulant, the clotting time is significantly prolonged. The test is typically performed in two stages: a screening test and a confirmatory test, with the latter involving the addition of excess phospholipids to distinguish between lupus anticoagulant and other inhibitors.
Procedure
The procedure for the dRVVT test involves collecting a blood sample from the patient, which is then centrifuged to obtain plasma. The Russell's viper venom and a phospholipid mixture are added to the plasma, and the time it takes for the blood to clot is measured. If the clotting time is prolonged, a confirmatory test is performed to verify the presence of lupus anticoagulant.
Clinical Significance
The dRVVT test is an essential tool in diagnosing Antiphospholipid Syndrome (APS), a disorder characterized by the presence of antiphospholipid antibodies that increase the risk of thrombosis. APS can lead to various complications, including deep vein thrombosis, stroke, and recurrent miscarriages. Early diagnosis and management of APS can significantly improve patient outcomes.
Limitations
While the dRVVT test is highly specific for lupus anticoagulant, it is not without limitations. Factors such as anticoagulant therapy, acute phase reactions, and the presence of other coagulation inhibitors can affect the test results. Therefore, the dRVVT test should be interpreted in conjunction with clinical findings and other laboratory tests.
Conclusion
The Dilute Russell's Viper Venom Time test is a valuable diagnostic tool in the field of hematology, particularly for identifying lupus anticoagulant and managing antiphospholipid syndrome. Its specificity and sensitivity make it a preferred method for diagnosing conditions associated with an increased risk of thrombosis.
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD