Donor lymphocyte infusion
Donor Lymphocyte Infusion
Donor Lymphocyte Infusion (Pronunciation: Doh-nor Lim-fo-site In-fyoo-zhun), often abbreviated as DLI, is a form of cancer treatment that involves the infusion of lymphocytes from a donor to a recipient, usually as part of a stem cell transplant procedure.
Etymology
The term "Donor Lymphocyte Infusion" is derived from the English language. "Donor" refers to the individual who provides the lymphocytes, "Lymphocyte" is a type of white blood cell that plays a crucial role in the immune system, and "Infusion" refers to the method of delivering these cells into the patient's bloodstream.
Procedure
In a Donor Lymphocyte Infusion, lymphocytes are collected from a donor who has previously donated stem cells to the recipient. These lymphocytes are then infused into the patient's bloodstream. The donor's immune cells can recognize and attack any remaining cancer cells, providing a "graft-versus-tumor" effect.
Uses
DLI is primarily used to treat relapses of leukemia and other blood cancers following a stem cell transplant. It can also be used to boost the immune system in patients who have low white blood cell counts after a transplant.
Risks and Complications
Potential risks and complications of DLI include Graft-versus-host disease (GVHD), a condition where the donor's immune cells attack the recipient's healthy cells, and infections due to a weakened immune system.
Related Terms
External links
- Medical encyclopedia article on Donor lymphocyte infusion
- Wikipedia's article - Donor lymphocyte infusion
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