Epimer
Epimer
An epimer is a type of diastereomer that differs in configuration at only one stereogenic center out of several. Epimers are a subset of diastereomers and are particularly important in the field of carbohydrate chemistry.
Definition
Epimers are stereoisomers that have multiple chiral centers but differ from each other in the configuration at only one of these centers. This means that while the molecules are not mirror images of each other (and thus not enantiomers), they are still stereoisomers because they have the same molecular formula and sequence of bonded atoms.
Examples
A classic example of epimers is the pair of monosaccharides D-glucose and D-mannose. These two sugars differ only in the configuration around the second carbon atom. Another example is D-glucose and D-galactose, which differ at the fourth carbon atom.
Biological Significance
Epimers play a crucial role in biochemistry, particularly in the structure and function of carbohydrates. Enzymes known as epimerases can catalyze the conversion of one epimer to another, which is essential in various metabolic pathways. For instance, the enzyme UDP-glucose 4-epimerase converts UDP-glucose to UDP-galactose, a critical step in the Leloir pathway of galactose metabolism.
Epimerization
The process of converting one epimer to another is called epimerization. This can occur through enzymatic action or under certain chemical conditions. Epimerization is an important reaction in the synthesis and modification of complex molecules, including pharmaceuticals.
Related Concepts
- Anomer: A type of epimer found in cyclic saccharides that differ in configuration only at the anomeric carbon.
- Diastereomer: Stereoisomers that are not mirror images of each other and have different physical properties.
- Enantiomer: Stereoisomers that are non-superimposable mirror images of each other.
See Also
References
External Links
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