Eprosartan

Overview of the antihypertensive drug Eprosartan

Eprosartan
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Eprosartan is an angiotensin II receptor antagonist used primarily for the treatment of hypertension. It is part of the class of medications known as angiotensin receptor blockers (ARBs), which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict.

Pharmacology

Eprosartan functions by selectively blocking the binding of angiotensin II to the angiotensin II receptor type 1 (AT1 receptor) in various tissues, including vascular smooth muscle and the adrenal gland. This action leads to vasodilation and a reduction in blood pressure.

Mechanism of Action

Structural formula of Eprosartan

Eprosartan inhibits the effects of angiotensin II by preventing its binding to the AT1 receptor. Angiotensin II is a potent vasoconstrictor and a key component of the renin-angiotensin system, which regulates blood pressure and fluid balance. By blocking this pathway, eprosartan reduces peripheral vascular resistance and lowers blood pressure.

Pharmacokinetics

Eprosartan is administered orally and is absorbed through the gastrointestinal tract. It has a bioavailability of approximately 13% and reaches peak plasma concentrations within 1 to 2 hours after ingestion. The drug is primarily excreted unchanged in the urine and feces.

Clinical Use

Eprosartan is indicated for the management of hypertension. It may be used alone or in combination with other antihypertensive agents, such as diuretics or calcium channel blockers.

Dosage and Administration

The typical starting dose of eprosartan is 600 mg once daily. The dose may be adjusted based on the patient's response and clinical condition. It is important to monitor blood pressure regularly to ensure optimal control.

Side Effects

Common side effects of eprosartan include dizziness, headache, and fatigue. These effects are generally mild and transient. Serious adverse effects are rare but may include angioedema and renal impairment.

Contraindications

Eprosartan is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should not be used during pregnancy due to the risk of fetal harm.

Related pages

• Angiotensin II receptor antagonist
• Hypertension
• Renin-angiotensin system