Ergocryptine
Ergocryptine is an ergopeptine and one of the ergot alkaloids. It is a precursor for the synthesis of bromocriptine.
Chemistry[edit]
Ergocryptine is a complex molecule of the ergoline family. It contains a tripeptide structure attached to the basic ergoline ring in the same orientation as ergotamine, but it is unique among the ergopeptines in that it contains α-aminobutyric acid in its peptide moiety.
Biosynthesis[edit]
Ergocryptine is a secondary metabolite produced by the fungus Claviceps purpurea. The biosynthesis of ergocryptine begins with the condensation of L-tryptophan and dimethylallyl pyrophosphate to form the tetracyclic ergoline ring system.
Pharmacology[edit]
Ergocryptine acts as a potent dopamine receptor agonist. It has been used in the treatment of Parkinson's disease and other medical conditions.
See also[edit]
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References[edit]
External links[edit]
- Ergocryptine at PubChem
- Ergocryptine at DrugBank
Further reading[edit]
- Smith, A., & Pennington, R. J. (1975). Ergocryptine and other constituents of ergot. Journal of the Chemical Society, Perkin Transactions 1, (0), 2375-2378.
- Schardl, C. L., Panaccione, D. G., & Tudzynski, P. (2006). Ergot alkaloids--biology and molecular biology. The Alkaloids: Chemistry and Biology, 63, 45-86.
Ergocryptine[edit]
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Ergocryptine
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Ergot alkaloid biosynthesis
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Part 3 in biosynthesis of ergocryptine
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Detail look at mechanism in biosynthesis of ergocryptine
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Part 4 in biosynthesis of ergot alkaloid ergocryptine
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Part 5 in the biosynthesis of ergocryptine
