Estradiol butyrylacetate

Estradiol butyrylacetate (pronunciation: es-tra-DYE-ol byoo-TEER-il-AS-e-tate) is a synthetic, steroidal estrogen that is used in hormone therapy. It is a prodrug of estradiol in the body, where it is converted into estradiol by esterases.

Etymology

The term "Estradiol butyrylacetate" is derived from the parent compound estradiol, and the addition of butyrylacetate, which refers to the esterification of the parent compound. The term "estradiol" is derived from estra-, which is a prefix that refers to estrus, and -diol, a chemical term denoting a compound with two hydroxyl (-OH) groups.

Pharmacology

Estradiol butyrylacetate is a prodrug of estradiol, meaning it is biologically inactive itself but is metabolized in the body to produce the active hormone, estradiol. This conversion is carried out by enzymes known as esterases, which remove the butyrylacetate group from the molecule.

Clinical Use

Estradiol butyrylacetate is used in hormone therapy, such as in the treatment of menopausal symptoms, hypoestrogenism, and in hormone therapy for transgender women. It is usually administered by intramuscular injection.

Related Terms

• Estradiol
• Prodrug
• Esterase
• Hormone therapy
• Menopause
• Hypoestrogenism
• Transgender hormone therapy

See Also

• List of estrogen esters
• List of hormonal cytostatic antineoplastic agents

External links

• Medical encyclopedia article on Estradiol butyrylacetate
• Wikipedia's article - Estradiol butyrylacetate

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