Exophthalmos

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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Exophthalmos
Synonyms	Proptosis
Pronounce	N/A
Specialty	N/A
Symptoms	Bulging eyes, dry eyes, irritation, double vision
Complications	Corneal ulcer, vision loss
Onset	Any age
Duration	Variable
Types	N/A
Causes	Graves' disease, orbital cellulitis, orbital tumor, trauma
Risks	Hyperthyroidism, autoimmune disorders
Diagnosis	Physical examination, imaging studies
Differential diagnosis	Orbital pseudotumor, thyroid eye disease, orbital cellulitis
Prevention	N/A
Treatment	Corticosteroids, radiation therapy, surgery
Medication	N/A
Prognosis	Variable, depends on underlying cause
Frequency	Common in Graves' disease
Deaths	N/A

Exophthalmos observed in a patient with Graves' Disease.

Exophthalmos, also known as proptosis, is a medical condition characterized by the anterior displacement or bulging of one or both eyes within the orbit. This condition can be a sign of various underlying health issues, most notably thyroid eye disease (TED), also known as Graves' orbitopathy. Exophthalmos can affect one or both eyes and ranges from mild to severe, potentially leading to significant discomfort and vision problems.

Causes

Exophthalmos can result from several conditions, including:

• Thyroid Eye Disease (TED): The most common cause, associated with hyperthyroidism.
• Orbital tumors: Benign or malignant growths within the orbit that push the eye forward.
• Infections: Such as orbital cellulitis, which can cause swelling behind the eye.
• Inflammatory conditions: Like sarcoidosis or Wegener's granulomatosis.
• Vascular problems: Including cavernous sinus thrombosis and carotid-cavernous fistula.

Symptoms

Symptoms of exophthalmos may include:

• Visible bulging of the eyes
• Dry or irritated eyes
• Excessive tearing
• Difficulty closing the eyes completely
• Altered vision or double vision (diplopia)
• Sensitivity to light

Diagnosis

Diagnosing exophthalmos involves a comprehensive evaluation, including:

• Clinical examination
• Imaging studies, such as CT scans or Magnetic Resonance Imaging (MRI), to view the orbit and assess for underlying causes.
• Blood tests, especially to assess thyroid function in cases suspected to be related to TED.

Treatment

Treatment of exophthalmos focuses on the underlying cause:

• For TED, options may include selenium supplements, steroids, radiotherapy, or surgery.
• Management of orbital tumors might involve surgery, radiation, or chemotherapy.
• Infections require prompt antibiotic treatment.
• Lubricating eye drops and ointments can help manage symptoms of dryness and exposure.

Complications

If left untreated, exophthalmos can lead to serious complications, including:

• Corneal abrasion
• Vision loss
• Diplopia
• Cosmetic concerns affecting psychological well-being

See Also

• Orbital decompression surgery
• Graves' disease
• Orbital cellulitis
• Thyroid function tests

External Links

• American Thyroid Association - Thyroid Eye Disease
• American Academy of Ophthalmology - What is Proptosis?

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