Factor XI
Factor XI
Factor XI or Plasma Thromboplastin Antecedent is one of the enzymes that participate in the blood coagulation process. It is also known as FXI or PTA.
Pronunciation
Factor XI is pronounced as "Factor Eleven".
Etymology
The term "Factor XI" is derived from the classification of blood clotting factors that was established in the mid-20th century. The Roman numeral XI signifies that it was the 11th clotting factor to be discovered.
Function
Factor XI is a zymogen that is activated to Factor XIa by Factor XII and in turn, Factor XIa activates Factor IX. This is a crucial step in the coagulation cascade, which leads to the formation of a blood clot.
Related Terms
- Hemophilia: A group of hereditary genetic disorders that impair the body's ability to control blood clotting.
- Factor XI Deficiency: A rare genetic disorder characterized by an increased risk of bleeding due to a reduction in the level of Factor XI.
- Coagulation: The process by which blood changes from a liquid to a gel, forming a clot.
- Zymogen: An inactive enzyme precursor that requires a biochemical change for it to become an active enzyme.
See Also
External links
- Medical encyclopedia article on Factor XI
- Wikipedia's article - Factor XI
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