Factor vii
Factor VII
Factor VII (pronounced as "factor seven") is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class.
Etymology
The term "Factor VII" is derived from the fact that it is the seventh identified factor in the coagulation cascade, a series of reactions that stop bleeding. The coagulation factors are traditionally numbered using Roman numerals, hence "VII".
Function
Factor VII is produced in the liver and released into the bloodstream. When tissue damage results in bleeding, factor VII is activated and interacts with tissue factor (TF). The resulting complex (TF-FVIIa) then activates factor IX and factor X, which leads to the formation of a blood clot.
Related Terms
- Coagulation: The process by which blood changes from a liquid to a gel, forming a clot.
- Tissue factor: A protein that plays a crucial role in the blood coagulation cascade.
- Factor IX: Another protein in the coagulation cascade, which is activated by the TF-FVIIa complex.
- Factor X: A protein that plays a key role in the coagulation cascade, leading to the formation of a blood clot.
Deficiency
A deficiency of Factor VII, known as Factor VII deficiency, is a rare genetic disorder characterized by a lack of Factor VII in the blood, leading to prolonged bleeding.
Treatment
Treatment for Factor VII deficiency typically involves replacement therapy, where the missing Factor VII is replaced with recombinant Factor VIIa.
External links
- Medical encyclopedia article on Factor vii
- Wikipedia's article - Factor vii
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