Ferric derisomaltose
Ferric Derisomaltose is a type of intravenous iron preparation used in the treatment of iron deficiency anemia. It is also known by the brand name Monoferric.
Composition
Ferric derisomaltose is composed of iron (III) hydroxide and derisomaltose, a carbohydrate complex. The iron is present in the ferric (Fe3+) state. The complex is designed to slowly release iron, allowing the body to use it to produce hemoglobin and other iron-containing proteins.
Indications
Ferric derisomaltose is indicated for the treatment of iron deficiency anemia in adults who have intolerance or unresponsiveness to oral iron therapy. It is also used in conditions where rapid iron replenishment is required, such as in cases of significant blood loss or in patients with chronic kidney disease.
Administration
Ferric derisomaltose is administered intravenously, usually in a hospital or clinic setting. The dose and frequency of administration depend on the patient's iron levels and clinical condition.
Side Effects
Common side effects of ferric derisomaltose include nausea, constipation, diarrhea, and injection site reactions. Serious side effects can include allergic reactions and hypersensitivity reactions, including anaphylaxis.
Contraindications
Ferric derisomaltose is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with iron overload syndromes, such as hemochromatosis.
Interactions
Ferric derisomaltose can interact with certain medications, including those that affect iron absorption or utilization. It can also interfere with certain laboratory tests, including serum iron and transferrin saturation.
Pharmacology
Ferric derisomaltose is a complex that dissociates slowly in the blood, releasing iron that can be used by the body. The iron is taken up by reticuloendothelial system cells and incorporated into hemoglobin and other iron-containing proteins.
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