Fibrinoid necrosis
Fibrinoid Necrosis
Fibrinoid necrosis (pronunciation: /ˈfaɪbrɪnɔɪd nɛˈkrəʊsɪs/) is a specific type of necrosis or tissue death, characterized by the presence of fibrin-like substances in the affected tissues.
Etymology
The term "fibrinoid necrosis" is derived from the words "fibrin", a protein involved in blood clotting, and "necrosis", which refers to the death of cells or tissues. The suffix "-oid" means "resembling" or "like", indicating that the substances found in this type of necrosis resemble fibrin.
Definition
Fibrinoid necrosis is a form of necrosis that is typically seen in immune reactions involving blood vessels. It is characterized by the accumulation of antigen-antibody complexes, resulting in the deposition of fibrin-like material.
Related Terms
- Necrosis: The death of cells or tissues from severe injury or disease, especially in a localized area of the body.
- Fibrin: A fibrous non-globular protein involved in the clotting of blood.
- Antigen: A substance that induces an immune response, especially the production of antibodies.
- Antibody: A blood protein produced in response to and counteracting a specific antigen.
Pathogenesis
Fibrinoid necrosis is most commonly associated with conditions such as rheumatoid arthritis, systemic lupus erythematosus, and polyarteritis nodosa. It occurs when immune complexes are deposited in the walls of blood vessels, leading to activation of the complement system and resulting in inflammation and necrosis.
Clinical Significance
Fibrinoid necrosis is a significant finding in many autoimmune diseases. It is indicative of severe vascular damage and can lead to serious complications if not properly managed.
External links
- Medical encyclopedia article on Fibrinoid necrosis
- Wikipedia's article - Fibrinoid necrosis
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