Flumazenil
Flumazenil
Flumazenil (pronounced floo-MAZ-eh-nil) is a selective GABA receptor antagonist that is primarily used in the treatment of benzodiazepine overdoses. It is also occasionally used in the reversal of sedation caused by benzodiazepines during surgical procedures or diagnostic tests.
Etymology
The term "Flumazenil" is derived from the Latin "flumen", meaning "river", and "zenil", a term of unknown origin. The name was likely chosen for its unique sound and ease of pronunciation.
Pharmacology
Flumazenil works by competitively inhibiting the action of benzodiazepines on the GABA receptor, thereby reversing the sedative effects of the benzodiazepines. It has a high affinity for the benzodiazepine receptor site and is able to displace benzodiazepines from this site.
Clinical Uses
Flumazenil is primarily used in the treatment of benzodiazepine overdoses. It can rapidly reverse the sedative and respiratory depressant effects of benzodiazepines, making it a critical tool in emergency medicine. It is also used in the reversal of sedation caused by benzodiazepines during surgical procedures or diagnostic tests.
Side Effects
Common side effects of Flumazenil include dizziness, nausea, vomiting, and agitation. In rare cases, it can cause seizures, particularly in patients with a history of epilepsy or severe benzodiazepine dependence.
Related Terms
External links
- Medical encyclopedia article on Flumazenil
- Wikipedia's article - Flumazenil
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