GRK4
- G protein-coupled receptor kinase 4 (GRK4) is an enzyme that in humans is encoded by the GRK4 gene. This encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most highly similar to GRK5 and GRK6. GRK4 is most highly expressed in the testes, with low amounts in brain and kidney and other tissues, and has four alternatively-spliced variants. Polymorphisms in the GRK4 have been linked to both genetic and acquired hypertension, acting in part through kidney dopamine receptors. [[Category:Uncategorized
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Contributors: Prab R. Tumpati, MD
