GSK-4112

GSK-4112

Chemical structure of GSK-4112

GSK-4112 is a synthetic chemical compound that acts as a selective ligand for the nuclear receptor Rev-ErbA alpha. It is primarily used in research to study the physiological roles of Rev-ErbA alpha, which is involved in the regulation of circadian rhythm, metabolism, and inflammation.

Mechanism of Action

GSK-4112 functions as an agonist of the Rev-ErbA alpha receptor. By binding to this receptor, GSK-4112 influences the transcription of genes involved in various biological processes. The activation of Rev-ErbA alpha by GSK-4112 leads to the repression of target genes, which can affect the circadian clock, lipid metabolism, and glucose homeostasis.

Biological Effects

The activation of Rev-ErbA alpha by GSK-4112 has been shown to have several biological effects:

• Circadian Rhythm Regulation: GSK-4112 can modulate the expression of core clock genes, thereby influencing the circadian rhythm.
• Metabolic Effects: It affects lipid and glucose metabolism, potentially offering insights into the treatment of metabolic disorders.
• Inflammation: GSK-4112 has been studied for its role in modulating inflammatory responses, which could have implications for diseases characterized by chronic inflammation.

Research Applications

GSK-4112 is used extensively in biomedical research to explore the functions of Rev-ErbA alpha. It serves as a tool compound to dissect the pathways regulated by this nuclear receptor and to understand its role in various physiological and pathological conditions.

Related Pages

• Rev-ErbA alpha
• Circadian rhythm
• Nuclear receptor
• Metabolism