GW-9662

Overview

GW-9662 is a synthetic chemical compound that acts as a selective antagonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It is primarily used in scientific research to study the role of PPARγ in various biological processes, including metabolism, inflammation, and cancer.

Chemical Structure and Properties

GW-9662 is chemically known as 2-chloro-5-nitro-N-phenylbenzamide. It is characterized by its aromatic benzamide structure, which includes a nitro group and a chlorine atom that contribute to its activity as a PPARγ antagonist. The molecular formula of GW-9662 is C13H9ClN2O3, and it has a molecular weight of 276.68 g/mol.

Mechanism of Action

GW-9662 functions by binding to the ligand-binding domain of PPARγ, thereby inhibiting its activity. PPARγ is a nuclear receptor that regulates the expression of genes involved in glucose and lipid metabolism, adipocyte differentiation, and inflammation. By blocking PPARγ, GW-9662 can modulate these pathways, making it a valuable tool for studying metabolic diseases and inflammatory conditions.

Applications in Research

GW-9662 is widely used in preclinical studies to investigate the role of PPARγ in various diseases. Some of the key areas of research include:

• Metabolic Disorders: GW-9662 is used to study the effects of PPARγ inhibition on insulin sensitivity, glucose homeostasis, and lipid metabolism, providing insights into conditions such as type 2 diabetes and obesity.

• Inflammation: Researchers use GW-9662 to explore the anti-inflammatory properties of PPARγ and its potential therapeutic applications in diseases like rheumatoid arthritis and inflammatory bowel disease.

• Cancer: The compound is also employed in cancer research to understand the role of PPARγ in tumorigenesis and cancer progression, particularly in breast cancer and colon cancer.

Safety and Handling

As with many research chemicals, GW-9662 should be handled with care. It is important to follow appropriate safety protocols, including the use of personal protective equipment and working in a well-ventilated area. The compound should be stored in a cool, dry place, away from light and moisture.

Also see

• Peroxisome proliferator-activated receptor gamma
• Type 2 diabetes
• Obesity
• Rheumatoid arthritis
• Breast cancer

External Links

• [PubChem entry for GW-9662](https://pubchem.ncbi.nlm.nih.gov/compound/GW-9662)
• [Research articles on GW-9662](https://www.ncbi.nlm.nih.gov/pubmed/?term=GW-9662)

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