Glucose-6-phosphate dehydrogenase

Glucose tolerance refers to the body's ability to metabolize glucose, a simple sugar that serves as a primary source of energy. It is a key aspect of carbohydrate metabolism and is crucial in the understanding and management of conditions such as diabetes mellitus and insulin resistance.

Overview

Glucose is a primary energy source for the body's cells. The body's ability to metabolize glucose effectively is known as glucose tolerance. This process is regulated by the hormone insulin, which is produced by the pancreas. Insulin facilitates the uptake of glucose into cells, where it is used for energy.

Glucose Tolerance Test

A Glucose Tolerance Test (GTT) is a medical test that measures the body's ability to metabolize glucose. It is often used to diagnose conditions such as gestational diabetes, Type 2 diabetes, and prediabetes. The test involves fasting overnight, then consuming a glucose-rich drink. Blood glucose levels are then measured at regular intervals to assess how effectively the body metabolizes the glucose.

Impaired Glucose Tolerance

Impaired Glucose Tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology. IGT may precede Type 2 diabetes by many years. IGT is also a risk factor for mortality.

See Also

• Diabetes mellitus
• Insulin resistance
• Metabolic syndrome
• Hyperglycemia

References

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Glucose-6-phosphate dehydrogenase

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  Labeled sites of G6PD

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  Labeled active site of G6PD

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  Hydrogen bonding at G6PD structural site

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  Hydrophobic interactions at G6PD structural site

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  Pathology of G6PD deficiency