Hexestrol diacetate
Hexestrol diacetate is a synthetic, nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol that is used as a growth promoter in animals. It is not used in humans, but is important in veterinary medicine.
Chemical Structure
Hexestrol diacetate is a synthetic, nonsteroidal estrogen that is structurally related to diethylstilbestrol. It is a white, crystalline solid that is soluble in organic solvents and slightly soluble in water. The chemical formula is C20H22O4 and the molecular weight is 326.39 g/mol.
Pharmacology
Hexestrol diacetate is a potent estrogen receptor agonist. It binds to the estrogen receptor and activates it, leading to an increase in the transcription of estrogen-responsive genes. This results in the promotion of growth and development in animals.
Uses
Hexestrol diacetate is used as a growth promoter in animals. It is not used in humans due to its potential for causing serious side effects, including cancer. In veterinary medicine, it is used to promote weight gain and improve feed efficiency in livestock.
Side Effects
The use of hexestrol diacetate in animals can lead to a number of side effects, including reproductive abnormalities, liver damage, and an increased risk of cancer. It is also a potential environmental pollutant due to its persistence in the environment and its ability to bioaccumulate in animal tissues.
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Contributors: Prab R. Tumpati, MD
