Non-Langerhans cell histiocytosis

Non-Langerhans cell histiocytosis
Synonyms	Histiocytosis X, Erdheim–Chester disease, Juvenile xanthogranuloma
Pronounce	N/A
Specialty	N/A
Symptoms	Skin lesions, Bone pain, Diabetes insipidus, Exophthalmos
Complications	Organ failure, Neurological complications
Onset	Variable, can occur at any age
Duration	Chronic
Types	N/A
Causes	Unknown, possibly genetic mutations
Risks	Unknown
Diagnosis	Biopsy, Imaging studies, Blood tests
Differential diagnosis	Langerhans cell histiocytosis, Sarcoidosis, Lymphoma
Prevention	N/A
Treatment	Corticosteroids, Chemotherapy, Radiation therapy
Medication	N/A
Prognosis	Variable, depends on organ involvement
Frequency	Rare
Deaths	N/A

Non-Langerhans cell histiocytosis is a group of rare diseases characterized by the accumulation of non-Langerhans cells, which are a type of white blood cell, in various organs and tissues. These diseases can affect both children and adults.

Classification

Non-Langerhans cell histiocytosis can be classified into several types, including Rosai-Dorfman disease, Juvenile xanthogranuloma, Erdheim-Chester disease, and Reticulohistiocytosis. Each of these diseases has unique clinical features and may affect different organs and tissues.

Symptoms

The symptoms of non-Langerhans cell histiocytosis vary depending on the specific type of disease and the organs and tissues affected. Common symptoms may include skin lesions, bone pain, and organ dysfunction.

Diagnosis

The diagnosis of non-Langerhans cell histiocytosis is typically made based on a combination of clinical findings, imaging studies, and histopathological examination of tissue samples. Immunohistochemical staining is often used to confirm the diagnosis.

Treatment

The treatment of non-Langerhans cell histiocytosis depends on the specific type of disease and the severity of symptoms. Treatment options may include surgery, radiation therapy, chemotherapy, and targeted therapies.

Prognosis

The prognosis of non-Langerhans cell histiocytosis varies widely depending on the specific type of disease and the organs and tissues affected. Some forms of the disease are self-limiting and resolve without treatment, while others may be chronic or life-threatening.

See also

• Histiocytosis
• Langerhans cell histiocytosis
• Histiocyte

References

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