Hydrolase

Hydrolase is a type of enzyme that is primarily involved in biochemical reactions that use water to break a chemical bond, a process known as hydrolysis. This class of enzymes plays a crucial role in a variety of biological processes, including digestion, metabolism, and immune response.

Structure and Function

Hydrolases are characterized by their ability to accelerate the rate of hydrolysis, a reaction in which water is used to break a chemical bond. They achieve this by lowering the activation energy required for the reaction to occur. The structure of a hydrolase enzyme is typically composed of a protein molecule, which provides a specific site, known as the active site, where the substrate can bind and undergo a chemical reaction.

Classification

Hydrolases are classified under the EC number 3 in the Enzyme Commission classification system. They are further divided into subclasses based on the type of bond they hydrolyze. Some of the major subclasses include:

• EC 3.1: Esterases - enzymes that hydrolyze ester bonds.
• EC 3.2: Glycosidases - enzymes that hydrolyze glycosidic bonds.
• EC 3.3: Etherases - enzymes that hydrolyze ether bonds.
• EC 3.4: Peptidases - enzymes that hydrolyze peptide bonds.
• EC 3.5: Amidases - enzymes that hydrolyze amide bonds.
• EC 3.6: Phosphatases - enzymes that hydrolyze phosphate ester bonds.

Role in Disease

Abnormalities in hydrolase function can lead to a variety of diseases. For example, deficiencies in specific hydrolases can result in lysosomal storage disease, a group of rare genetic disorders characterized by the accumulation of waste materials in cells. On the other hand, overactivity of certain hydrolases can contribute to inflammatory diseases and cancer.

See Also

• Enzyme kinetics
• Enzyme inhibitor
• Enzyme activator

References

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