Hyoscine butylbromide
Hyoscine butylbromide (pronunciation: hi-OH-seen BYOO-tuhl-BROH-mide), also known as scopolamine butylbromide and sold under the brand name Buscopan among others, is a medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. It is also used to improve respiratory secretions at the end of life. Hyoscine butylbromide is taken by mouth, injection into a muscle, or into a vein.
Etymology
The term "Hyoscine" is derived from the plant genus name Hyoscyamus, from which the drug was first isolated. The genus name Hyoscyamus comes from the Greek words "hyos" (pig) and "kyamos" (bean), referring to the use of the plant's seeds to poison pigs in ancient times. "Butylbromide" refers to the butyl bromide component of the molecule, which aids in the drug's antispasmodic effects.
Pharmacology
Hyoscine butylbromide is an anticholinergic drug, meaning it blocks the action of the neurotransmitter acetylcholine at its receptor in nerve cells. This prevents the increase in intracellular concentration of Ca++ which is caused by the interaction of acetylcholine with the muscarinic receptors, thus causing relaxation of smooth muscle in the gastrointestinal and urinary tracts.
Side Effects
Common side effects include dry mouth, sleepiness, urinary retention, and blurred vision. It is unclear if use is safe during pregnancy. It is in the antimuscarinic family of medications and works by decreasing the movements of the stomach and intestines.
See Also
External links
- Medical encyclopedia article on Hyoscine butylbromide
- Wikipedia's article - Hyoscine butylbromide
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