ILC2

ILC development 2 PNG

Innate lymphoid cell type 2 (ILC2)

Innate lymphoid cell type 2 (ILC2) is a subset of innate lymphoid cells that play a crucial role in the immune response. ILC2s are primarily involved in the regulation of type 2 immune responses, which are important for defense against helminth parasites and in allergic reactions.

Structure and Function

ILC2s are characterized by the expression of specific surface markers, including CD127 and CRTH2. They are primarily located in barrier tissues such as the lungs, skin, and gut, where they respond to various stimuli such as cytokines and tissue-derived factors.

ILC2s are known to produce a variety of cytokines, including IL-5 and IL-13, which are important for the recruitment and activation of other immune cells involved in type 2 immune responses. Additionally, ILC2s can interact with other immune cells, such as mast cells and eosinophils, to coordinate the immune response.

Regulation

The activity of ILC2s is tightly regulated by various factors, including cytokines such as IL-33 and IL-25, as well as transcription factors like GATA3. Dysregulation of ILC2 function has been implicated in various diseases, including asthma, allergic rhinitis, and inflammatory bowel disease.

Clinical Implications

Due to their role in type 2 immune responses, ILC2s have emerged as potential therapeutic targets for the treatment of allergic and inflammatory diseases. Modulating the activity of ILC2s may offer new strategies for managing these conditions and improving patient outcomes.

See also

• Innate lymphoid cell
• Immune response
• Type 2 immunity

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