Ibudilast
Ibudilast (pronounced as i-bu-di-last) is a non-selective phosphodiesterase inhibitor that has been used for its anti-inflammatory and bronchodilator effects in the treatment of asthma and post-stroke complications. It is also being investigated for its potential use in multiple sclerosis and drug addiction.
Etymology
The term "Ibudilast" is derived from its chemical name, 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine.
Pharmacology
Ibudilast inhibits several phosphodiesterase (PDE) enzymes, which leads to an increase in intracellular cyclic AMP levels. This results in the inhibition of tumor necrosis factor-alpha (TNF-alpha) and leukotriene synthesis, both of which are involved in the inflammatory response.
Clinical Use
Ibudilast has been used in Japan for many years to treat asthma and post-stroke complications. More recently, it has been investigated for its potential use in the treatment of multiple sclerosis and drug addiction.
Related Terms
- Phosphodiesterase inhibitor
- Cyclic AMP
- Tumor necrosis factor-alpha
- Leukotriene
- Asthma
- Multiple sclerosis
- Drug addiction
External links
- Medical encyclopedia article on Ibudilast
- Wikipedia's article - Ibudilast
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