Iflaviridae

The Iflaviridae is a family of viruses within the order Picornavirales. This family is composed of viruses that primarily infect insects, particularly honey bees and other pollinators. The family is named after the type genus Iflavirus.

Characteristics

Iflaviridae are small, non-enveloped viruses with a single-stranded, positive-sense RNA genome. The genome is approximately 9-10 kilobases in length and encodes a single large polyprotein that is processed into functional viral proteins. The virions are icosahedral in shape, with a diameter of about 30 nm.

Genome

The genome of Iflaviridae is linear and consists of a single open reading frame (ORF) that is translated into a polyprotein. This polyprotein is subsequently cleaved by viral proteases into structural and non-structural proteins. The 5' end of the genome is covalently linked to a viral protein (VPg), and the 3' end is polyadenylated.

Replication

Replication of Iflaviridae occurs in the cytoplasm of the host cell. The virus attaches to the host cell surface and enters via endocytosis. Once inside, the viral RNA is released and translated into the polyprotein. The polyprotein is cleaved to form the viral replication complex, which synthesizes new viral RNA genomes. These genomes are then packaged into new virions, which are released from the host cell to infect new cells.

Hosts and Transmission

Iflaviridae primarily infect insects, with a significant impact on honey bee populations. Transmission can occur vertically from parent to offspring or horizontally through contact with infected individuals or contaminated surfaces. Some iflaviruses are associated with colony collapse disorder in honey bees, making them a subject of interest in entomology and apiculture.

Pathogenesis

Infection with iflaviruses can lead to a range of symptoms in insects, from asymptomatic to severe, depending on the virus and host species. In honey bees, symptoms can include paralysis, reduced foraging ability, and increased mortality, which can contribute to colony collapse.

Research and Importance

Research on Iflaviridae is important for understanding the health of pollinator populations and the ecological and economic impacts of viral infections. Studies focus on virus-host interactions, mechanisms of pathogenesis, and potential strategies for controlling viral spread in bee populations.

Also see

• Picornavirales
• Honey bee viruses
• Colony collapse disorder
• RNA virus

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Iflaviridae

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  Iflaviridae virus structure

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  Iflaviridae genome organization

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  Iflaviridae phylogenetic tree

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  Iflaviridae classification