KCNK17

KCNK17 is a protein that in humans is encoded by the KCNK17 gene. KCNK17 is a member of the potassium channel family of proteins, which play a critical role in maintaining the electrical potential of cells, particularly neurons.

Function

KCNK17 is a member of the two-pore-domain potassium channel (K2P) family. This family of proteins forms ion channels that allow potassium ions to flow out of cells, which is crucial for maintaining the resting membrane potential of cells. KCNK17 is expressed in a variety of tissues, including the heart, brain, and kidney.

Structure

Like other members of the K2P family, KCNK17 is composed of four transmembrane domains with two pore-forming loops. The protein forms a dimer in the cell membrane, with each subunit forming one pore for potassium ions to pass through.

Clinical significance

Mutations in the KCNK17 gene have been associated with a variety of diseases, including cardiac arrhythmia and epilepsy. In addition, the protein has been implicated in the regulation of blood pressure and heart rate, making it a potential target for the treatment of hypertension and other cardiovascular diseases.

Research

Research into KCNK17 is ongoing, with studies focusing on its role in disease and its potential as a therapeutic target. For example, a 2018 study published in the journal Nature Communications found that KCNK17 plays a critical role in the regulation of heart rate and blood pressure.

See also

• Potassium channel
• Two-pore-domain potassium channel
• Cardiac arrhythmia
• Epilepsy

References

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