Large-cell lymphoma
Large-cell lymphoma
Large-cell lymphoma (pronunciation: lahrg-sel lim-foh-muh) is a type of non-Hodgkin lymphoma characterized by the presence of large, abnormal lymphocytes in the lymph nodes or other tissues.
Etymology
The term "large-cell lymphoma" is derived from the Latin lympha meaning "water", and the Greek -oma meaning "tumor". The term refers to the large size of the cancerous lymphocytes compared to normal ones.
Definition
Large-cell lymphoma is a broad category of lymphomas, including several subtypes such as diffuse large B-cell lymphoma (DLBCL), anaplastic large-cell lymphoma (ALCL), and primary mediastinal large B-cell lymphoma (PMBCL). These lymphomas are typically aggressive, meaning they grow quickly and require immediate treatment.
Symptoms
Symptoms of large-cell lymphoma can vary widely but often include swollen lymph nodes, fever, night sweats, and unexplained weight loss.
Diagnosis
Diagnosis of large-cell lymphoma typically involves a biopsy of an enlarged lymph node. The biopsy sample is then examined under a microscope to identify the presence of large, abnormal lymphocytes. Further tests such as imaging studies and blood tests may be used to determine the extent of the disease.
Treatment
Treatment for large-cell lymphoma often involves a combination of chemotherapy, radiation therapy, and in some cases, stem cell transplant. The choice of treatment depends on the specific subtype of large-cell lymphoma, the patient's overall health, and the extent of the disease.
Prognosis
The prognosis for large-cell lymphoma varies widely depending on the specific subtype, the patient's overall health, and how well the lymphoma responds to treatment. Some types of large-cell lymphoma, such as DLBCL, have a relatively good prognosis with appropriate treatment.
Related Terms
- Non-Hodgkin lymphoma
- Lymphocyte
- Lymph node
- Diffuse large B-cell lymphoma
- Anaplastic large-cell lymphoma
- Primary mediastinal large B-cell lymphoma
- Biopsy
- Chemotherapy
- Radiation therapy
- Stem cell transplant
External links
- Medical encyclopedia article on Large-cell lymphoma
- Wikipedia's article - Large-cell lymphoma
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