Lincosamides
Lincosamides
Lincosamides (pronunciation: lin-koh-sa-mides) are a class of antibiotic drugs that inhibit bacterial protein synthesis. They are derived from the compound lincomycin, which was isolated from the actinobacterium Streptomyces lincolnensis.
Etymology
The term "Lincosamides" is derived from lincolnensis, the species name of the bacterium from which lincomycin, the first lincosamide antibiotic, was isolated, and the suffix "-amide", which is used in organic chemistry to denote substances related to amides.
Mechanism of Action
Lincosamides work by binding to the 50S subunit of the bacterial ribosome, thereby inhibiting protein synthesis. This action is primarily bacteriostatic, but can be bactericidal in high concentrations or against susceptible bacteria.
Examples
Some examples of lincosamides include lincomycin and clindamycin. Clindamycin is often used to treat serious infections caused by susceptible anaerobic bacteria, as well as certain protozoal diseases.
Side Effects
Common side effects of lincosamides can include nausea, vomiting, diarrhea, and rash. More serious side effects can include Clostridium difficile associated diarrhea (CDAD) and allergic reactions.
Related Terms
- Antibiotic
- Lincomycin
- Clindamycin
- Ribosome
- Protein synthesis
- Bacteriostatic
- Bactericidal
- Anaerobic bacteria
- Protozoal diseases
- Clostridium difficile
- Allergic reactions
External links
- Medical encyclopedia article on Lincosamides
- Wikipedia's article - Lincosamides
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