Linopristin
Linopristin is a synthetic antibiotic that is part of the streptogramin group. It is used in the treatment of various bacterial infections, particularly those caused by Gram-positive bacteria. Linopristin is often used in combination with dalfopristin to form a drug known as quinupristin/dalfopristin.
Mechanism of Action
Linopristin works by inhibiting protein synthesis in bacteria. It binds to the 50S ribosomal subunit, preventing the addition of new amino acids to the growing peptide chain. This effectively halts the production of essential proteins, leading to the death of the bacteria.
Uses
Linopristin is used to treat a variety of bacterial infections, including skin infections, respiratory tract infections, and bloodstream infections. It is particularly effective against Gram-positive bacteria, such as Staphylococcus aureus and Enterococcus faecium.
Side Effects
Common side effects of linopristin include nausea, vomiting, and diarrhea. More serious side effects can include allergic reactions, liver damage, and blood disorders.
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