Malakoplakia

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Malakoplakia

Malakoplakia (pronounced: mal-uh-koh-PLAY-kee-uh) is a rare inflammatory condition that can affect various organs in the body. The term is derived from the Greek words "malakos" meaning soft and "plakos" meaning plaque, referring to the characteristic soft, yellow plaques found in affected tissues.

Etiology

The exact cause of malakoplakia is unknown, but it is believed to be associated with an abnormal immune response to bacterial infection, particularly infections caused by the Escherichia coli (E. coli) bacterium. Other bacteria, such as Proteus species and Staphylococcus species, have also been implicated.

Clinical Presentation

Malakoplakia can affect any organ in the body, but it most commonly affects the urinary tract, including the bladder and kidneys. Less commonly, it can affect the gastrointestinal tract, lungs, skin, and other organs. Symptoms vary depending on the organ affected, but may include abdominal pain, urinary symptoms, respiratory symptoms, or skin lesions.

Diagnosis

Diagnosis of malakoplakia is typically made based on the characteristic appearance of affected tissues under the microscope. This includes the presence of Michaelis-Gutmann bodies, which are unique inclusions found in the cells of malakoplakia lesions.

Treatment

Treatment of malakoplakia typically involves antibiotics to treat the underlying bacterial infection. In some cases, surgical removal of affected tissues may be necessary.

Prognosis

The prognosis of malakoplakia varies depending on the organ affected and the severity of the disease. With appropriate treatment, most people with malakoplakia can expect a good outcome.

See Also

References

External links

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