Mast cell
Mast cell is a type of white blood cell that plays a crucial role in the body's immune system. They are found in many tissues throughout the body, particularly in areas that are in close contact with the external environment, such as the skin, lungs, and digestive tract.
Function
Mast cells are involved in the body's defense against pathogens. They contain granules filled with various substances, including histamine and heparin, which are released in response to certain stimuli. This process, known as degranulation, is a key part of the body's inflammatory response.
Histamine, one of the substances released by mast cells, causes blood vessels to dilate and become more permeable, allowing other immune cells to reach the site of infection more easily. Heparin, on the other hand, prevents blood clotting, ensuring that blood can flow freely to the affected area.
Role in Allergic Reactions
Mast cells play a central role in allergic reactions. When an allergen enters the body, it binds to antibodies on the surface of mast cells. This triggers the mast cells to degranulate, releasing histamine and other substances. This causes the symptoms of an allergic reaction, such as itching, redness, and swelling.
In severe cases, this can lead to anaphylaxis, a life-threatening allergic reaction that requires immediate medical attention.
Disorders
There are several disorders associated with mast cells, including mastocytosis, a condition characterized by an excessive number of mast cells in the body. This can lead to a variety of symptoms, including skin lesions, abdominal pain, and bone pain.
Another disorder is mast cell activation syndrome (MCAS), in which the mast cells inappropriately release their granules, leading to a range of symptoms that can affect multiple systems in the body.
See Also
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Mast cell
Mast cells in bone marrow
Blausen 0018 Anaphylaxis
Mast cell
Mast cells
Histamine
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