Methoxphenidine

Methoxphenidine (also known as MXP) is a dissociative anesthetic that has been sold as a designer drug. It is a derivative of diphenidine and phenidine.

Chemistry

Methoxphenidine is part of the diarylethylamine class of dissociative anesthetics. Other members of this class include diphenidine and Ephenidine.

Pharmacology

Methoxphenidine acts as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually the same type of hallucinations seen with other dissociative drugs.

Effects

The effects of methoxphenidine are described by some as similar to ketamine or MXE, but with a longer duration. The effects are listed below:

• Physical effects: numbness, spatial disorientation, loss of motor control, tactile suppression, and perception of bodily lightness.
• Cognitive effects: derealization, depersonalization, time distortion, thought loops, and euphoria.
• Visual effects: double vision, pattern recognition enhancement, and scenery slicing.

Legal Status

Methoxphenidine is illegal in the UK under the Psychoactive Substances Act, which came into effect on May 26, 2016. It is also illegal in Sweden and Switzerland.

See Also

• Diphenidine
• Ephenidine
• Ketamine
• MXE

References

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