Mucociliary clearance

Mucociliary Clearance

Mucociliary clearance is a vital defense mechanism that protects the respiratory system from harmful particles, pathogens, and irritants. This process involves the coordinated action of mucus production and cilia movement to trap and remove foreign substances from the respiratory tract.

Mechanism

The mucociliary escalator is the primary mechanism of mucociliary clearance. The epithelial cells lining the respiratory tract produce a layer of mucus that traps inhaled particles. The cilia, tiny hair-like structures on the surface of these cells, beat in a coordinated fashion to move the mucus and trapped particles towards the pharynx, where they can be swallowed or expectorated.

Factors Affecting Mucociliary Clearance

Several factors can affect the efficiency of mucociliary clearance. These include the viscosity of the mucus, the speed and coordination of ciliary movement, and the presence of diseases or conditions such as cystic fibrosis, chronic obstructive pulmonary disease (COPD), and primary ciliary dyskinesia.

Clinical Significance

Impaired mucociliary clearance can lead to recurrent respiratory infections and chronic lung diseases. Therefore, understanding and maintaining the efficiency of this process is crucial in the prevention and management of these conditions.

See Also

• Respiratory System
• Cilia
• Mucus
• Cystic Fibrosis
• Chronic Obstructive Pulmonary Disease
• Primary Ciliary Dyskinesia

References

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  Bronchiolar epithelium under scanning electron microscope

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  Diagram of metachronal wave

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  Diagram of the respiratory tract