Myelodysplastic–myeloproliferative diseases

Group of diseases

Myelodysplastic–myeloproliferative diseases
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Synonyms	N/A
Pronounce	N/A
Field	Hematology
Symptoms	Fatigue, anemia, splenomegaly, fever
Complications	Acute myeloid leukemia, bone marrow failure
Onset
Duration
Types	Chronic myelomonocytic leukemia, Atypical chronic myeloid leukemia, Juvenile myelomonocytic leukemia
Causes
Risks
Diagnosis	Blood test, bone marrow biopsy
Differential diagnosis
Prevention	N/A
Treatment	Chemotherapy, stem cell transplant
Medication
Prognosis
Frequency
Deaths

Myelodysplastic–myeloproliferative diseases (MDS/MPN) are a group of hematologic disorders characterized by features of both myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). These diseases are marked by the abnormal growth and development of blood cells in the bone marrow, leading to a combination of cytopenias and cytoses.

Classification

Myelodysplastic–myeloproliferative diseases are classified into several subtypes, including:

• Chronic myelomonocytic leukemia (CMML)
• Atypical chronic myeloid leukemia (aCML)
• Juvenile myelomonocytic leukemia (JMML)
• Myelodysplastic/myeloproliferative neoplasm, unclassifiable (MDS/MPN-U)

Symptoms

Common symptoms of MDS/MPN include:

• Fatigue
• Anemia
• Splenomegaly
• Fever

Complications

Patients with MDS/MPN are at risk for developing:

• Acute myeloid leukemia (AML)
• Bone marrow failure

Diagnosis

Diagnosis of MDS/MPN typically involves:

• Blood tests to evaluate blood cell counts and morphology
• Bone marrow biopsy to assess the cellularity and presence of dysplastic or proliferative features

Treatment

Treatment options for MDS/MPN may include:

• Chemotherapy
• Stem cell transplant

Related Pages

• Hematology
• Myelodysplastic syndromes
• Myeloproliferative neoplasms
• Chronic myelomonocytic leukemia
• Atypical chronic myeloid leukemia
• Juvenile myelomonocytic leukemia
• Acute myeloid leukemia
• Bone marrow biopsy

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