FP-β-CPPIT

FP-β-CPPIT is a radiopharmaceutical compound used in PET imaging. It is a radioligand for the sigma receptor, specifically the sigma-1 receptor subtype.

Chemistry

FP-β-CPPIT is a fluorine-18 labeled compound. The fluorine-18 isotope is a positron emitter, which makes it suitable for PET imaging. The compound itself is a derivative of CPPIT, a known sigma-1 receptor ligand.

Use in Imaging

The primary use of FP-β-CPPIT is in PET imaging of the brain. The sigma-1 receptor is widely distributed in the brain, and its density can be indicative of various neurological and psychiatric conditions. By using FP-β-CPPIT as a radioligand, researchers can visualize the distribution and density of sigma-1 receptors in the brain.

Potential Applications

Research into the use of FP-β-CPPIT is ongoing. Potential applications include the study of neurodegenerative diseases, psychiatric disorders, and cancer. In neurodegenerative diseases, changes in sigma-1 receptor density may be indicative of disease progression. In psychiatric disorders, alterations in sigma-1 receptor function may be involved in the pathophysiology of the disorder. In cancer, sigma-1 receptors have been found to be overexpressed in certain types of tumors, making them a potential target for imaging and therapy.

See Also

• Radiopharmaceutical
• Positron emission tomography
• Sigma-1 receptor
• Fluorine-18
• CPPIT

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