NOS1

NOS1 or Neuronal Nitric Oxide Synthase is a protein that in humans is encoded by the NOS1 gene. It is one of three isoforms that synthesize nitric oxide, a small gaseous and lipophilic molecule that participates in several biological processes.

Function

NOS1 produces nitric oxide (NO) in neurons, where it plays a critical role in a variety of neurobiological functions. This includes neurotransmission, neurotoxicity, and the regulation of neuronal cell death. NOS1 is also involved in the regulation of vascular tone, insulin secretion, airway tone, and peristalsis, and is involved in angiogenesis and neural development.

Clinical significance

Alterations in the NOS1 gene have been associated with several diseases, including schizophrenia, attention deficit hyperactivity disorder (ADHD), bipolar disorder, and obsessive-compulsive disorder (OCD). In addition, NOS1 has been implicated in the pathogenesis of Alzheimer's disease and Parkinson's disease.

See also

• Nitric oxide synthase
• NOS2
• NOS3

External links

• NOS1 at the National Center for Biotechnology Information