Naltrexone/bupropion
Naltrexone/bupropion (pronunciation: nal-TREX-own/byoo-PROE-pee-on) is a combination medication used in the management of obesity and weight management in adults.
Etymology
The name "Naltrexone" is derived from "nallylnoroxymorphone" and "bupropion" is a coined term, with the "bu-" referring to butane, a hydrocarbon used in the initial synthesis of the drug.
Pharmacology
Naltrexone/bupropion combines two drugs, naltrexone, an opioid antagonist, and bupropion, an antidepressant, that act on the central nervous system to help control appetite and energy use. Naltrexone is thought to interfere with the parts of the brain that contribute to the pleasure and satisfaction associated with eating, and bupropion is believed to increase the number of calories that the body uses.
Indications
Naltrexone/bupropion is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:
- 30 kg/m² or greater (obese), or
- 27 kg/m² or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia).
Side Effects
Common side effects of naltrexone/bupropion include nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea. Serious side effects may include seizures, an increase in suicidal thoughts and behaviors, and an increase in blood pressure or heart rate.
Related Terms
External links
- Medical encyclopedia article on Naltrexone/bupropion
- Wikipedia's article - Naltrexone/bupropion
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