Nerolidol

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Nerolidol


Nerolidol (also known as Peruviol and Penetrol) is a naturally occurring sesquiterpene alcohol found in the essential oils of many types of plants and flowers. There are two isomers of nerolidol, cis and trans, which differ in the geometry about the central double bond. Nerolidol is present in neroli, ginger, jasmine, lavender, tea tree, Cannabis sativa, and lemon grass, and is a dominant scent compound in Brassavola nodosa, a species of orchid.

Chemistry

Nerolidol belongs to the class of organic compounds known as sesquiterpenoids, which are terpenes with three consecutive isoprene units. It is a colorless to pale yellow liquid with a woody and fresh bark-like smell. It is soluble in alcohol, but insoluble in water. The chemical formula of nerolidol is C15H26O.

Uses

Nerolidol is used extensively in the perfumery industry due to its pleasant fragrance. It is also used as a flavoring agent in food and beverages. In addition, nerolidol has been found to have several medicinal properties. It has been shown to possess antimicrobial, antifungal, antiparasitic, anticancer, and antioxidant properties. It also has potential uses in drug delivery systems due to its ability to enhance skin penetration of pharmaceuticals.

Health Effects

Research has shown that nerolidol has potential therapeutic properties. It has been found to be effective against a number of parasites, including malaria and leishmaniasis. It also has potential anticancer properties, with studies showing that it can inhibit the growth of various types of cancer cells. Furthermore, nerolidol has been found to have significant antioxidant activity, which can help to protect the body against damage by free radicals.

Safety

Nerolidol is generally considered safe for use. However, as with any substance, excessive or inappropriate use can lead to adverse effects. It is recommended to use nerolidol in moderation and to always follow the manufacturer's instructions.

See Also

References

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Contributors: Prab R. Tumpati, MD