Neurochemical
Neurochemicals are endogenous compounds that participate in neurotransmission. They include a variety of compounds such as neurotransmitters, neuropeptides, and psychopharmaceuticals. Neurochemicals are responsible for the maintenance of neuronal function and neural communication, and play a crucial role in neurological disorders and mental health.
Neurotransmitters
Neurotransmitters are a type of neurochemical that transmit signals across a neural synapse. They are released from the axon terminal of a neuron in response to an action potential, and bind to receptors on the post-synaptic neuron. This binding can either excite or inhibit the post-synaptic neuron, depending on the type of neurotransmitter and receptor involved.
Neuropeptides
Neuropeptides are small protein-like molecules used by neurons to communicate with each other. They are typically released from the dendrites of a neuron and act on receptors on the same neuron or on a nearby neuron. Neuropeptides have a wide range of functions, including modulating the activity of neurotransmitters, affecting mood and behavior, and regulating physiological processes such as pain perception and water balance.
Psychopharmaceuticals
Psychopharmaceuticals are drugs that affect the mind, emotions, and behavior by altering the function of neurochemicals in the brain. They include antidepressants, antipsychotics, anxiolytics, and mood stabilizers. Psychopharmaceuticals can be used to treat a variety of mental health conditions, including depression, anxiety disorders, bipolar disorder, and schizophrenia.
Role in Neurological Disorders and Mental Health
Neurochemicals play a crucial role in the development and progression of various neurological disorders and mental health conditions. Imbalances in neurotransmitters can lead to conditions such as Parkinson's disease, Alzheimer's disease, and major depressive disorder. Similarly, alterations in the function of neuropeptides can contribute to conditions such as chronic pain, obesity, and addiction. Psychopharmaceuticals are often used to correct these imbalances and alleviate symptoms.
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Contributors: Prab R. Tumpati, MD