Nortilidine
Nortilidine
Nortilidine (pronunciation: nor-til-i-deen) is a major active metabolite of the synthetic opioid analgesic tramadol. It is formed in the liver after the consumption of tramadol and is believed to possess more potent analgesic effects than its parent compound.
Etymology
The term "Nortilidine" is derived from the parent compound "Tramadol". The prefix "Nor-" is a common prefix in pharmacology used to denote a demethylated metabolite, which is the case for Nortilidine.
Pharmacology
Nortilidine binds to the mu-opioid receptor in the central nervous system, which is the same receptor that natural endorphins bind to. This binding action is responsible for the analgesic effects of Nortilidine. It also inhibits the reuptake of serotonin and norepinephrine, which contributes to its analgesic and mood-elevating effects.
Related Terms
- Tramadol: The parent compound from which Nortilidine is metabolized.
- Opioid: A class of drugs that includes Nortilidine, used primarily for their analgesic effects.
- Analgesic: A type of medication used to relieve pain, such as Nortilidine.
- Metabolite: A substance formed in or necessary for metabolism. In this case, Nortilidine is a metabolite of Tramadol.
- Serotonin: A neurotransmitter that contributes to feelings of well-being and happiness. Nortilidine inhibits its reuptake, enhancing its effects.
- Norepinephrine: A neurotransmitter involved in the body's stress response. Nortilidine inhibits its reuptake, enhancing its effects.
External links
- Medical encyclopedia article on Nortilidine
- Wikipedia's article - Nortilidine
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