Obatoclax
Obatoclax
Obatoclax (pronunciation: oh-ba-toe-clax) is a synthetic small molecule and potential antineoplastic agent. It is also known as Obatoclax mesylate or GX15-070MS.
Etymology
The term "Obatoclax" is derived from the combination of the words "obato" and "clax". The exact etymology is unknown as it is a synthetic compound and the name is likely derived from the chemical structure or the process used in its synthesis.
Description
Obatoclax is designed to inhibit all isoforms of the Bcl-2 family of proteins, which are often overexpressed in cancer cells and are associated with chemotherapy resistance. By inhibiting these proteins, Obatoclax may restore the natural cell death process (apoptosis) in cancer cells.
Related Terms
- Antineoplastic agents: These are drugs that inhibit and combat the development of tumors. Obatoclax is a potential antineoplastic agent.
- Bcl-2 family of proteins: A family of proteins that regulate cell death (apoptosis), including Bcl-2, Bcl-xL, Bcl-w, Mcl-1, and Bfl-1. Obatoclax is designed to inhibit all isoforms of these proteins.
- Apoptosis: A form of programmed cell death that occurs in multicellular organisms. Obatoclax may restore this process in cancer cells.
- Chemotherapy resistance: The resistance of cancer cells to chemotherapy, often due to overexpression of certain proteins like the Bcl-2 family of proteins.
External links
- Medical encyclopedia article on Obatoclax
- Wikipedia's article - Obatoclax
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