Oxendolone
Oxendolone is a synthetic steroid with antiandrogenic properties. It is primarily used in the treatment of conditions related to androgen excess, such as benign prostatic hyperplasia and acne.
Chemical Properties[edit]
Oxendolone is a derivative of nandrolone, a well-known anabolic steroid. Its chemical structure is characterized by the presence of a 17_-ethynyl group, which is responsible for its antiandrogenic activity. The molecular formula of Oxendolone is C20H28O3.
Mechanism of Action[edit]
Oxendolone acts as an antiandrogen by inhibiting the action of dihydrotestosterone (DHT) at the androgen receptor. This inhibition reduces the effects of androgens in target tissues, leading to a decrease in symptoms associated with androgen excess.
Clinical Uses[edit]
Oxendolone is used in the management of several conditions:
- Benign Prostatic Hyperplasia (BPH): By reducing the action of DHT, Oxendolone helps in alleviating the symptoms of BPH, such as urinary retention and frequent urination.
- Acne: The antiandrogenic effects of Oxendolone can help reduce the severity of acne by decreasing sebum production.
Side Effects[edit]
As with other antiandrogens, Oxendolone may cause side effects such as:
- Decreased libido
- Erectile dysfunction
- Gynecomastia
Pharmacokinetics[edit]
Oxendolone is administered orally and is metabolized in the liver. It has a relatively long half-life, allowing for once-daily dosing in most therapeutic regimens.
Related Compounds[edit]
Oxendolone is related to other antiandrogens such as cyproterone acetate and spironolactone. These compounds share similar mechanisms of action but differ in their chemical structures and specific clinical applications.
