Oxotremorine

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Oxotremorine

Oxotremorine (pronounced: ox-oh-trem-or-een) is a parasympathomimetic compound that acts as a direct agonist at muscarinic acetylcholine receptors. It is often used in scientific research to understand the function of these receptors.

Etymology

The term "Oxotremorine" is derived from its chemical structure, which contains an oxo group (a carbon atom double-bonded to an oxygen atom) and its ability to induce tremors as a side effect.

Pharmacology

Oxotremorine is a potent muscarinic receptor agonist. It binds to muscarinic receptors, mimicking the action of the neurotransmitter acetylcholine. This binding results in the activation of the receptor and subsequent physiological responses such as salivation, lacrimation, urination, defecation, gastrointestinal upset, and emesis - collectively known as the SLUDGE syndrome.

Clinical Use

While Oxotremorine is not typically used in clinical practice due to its side effects, it is a valuable tool in research for studying the function and role of muscarinic receptors in the body and brain. It has been used in studies investigating Alzheimer's disease, Parkinson's disease, and other neurological disorders.

Related Terms

  • Parasympathomimetic: A type of drug that stimulates the parasympathetic nervous system.
  • Agonist: A substance that initiates a physiological response when combined with a receptor.
  • Muscarinic acetylcholine receptors: A type of receptor in the nervous system that responds to the neurotransmitter acetylcholine.
  • Acetylcholine: A neurotransmitter in the nervous system responsible for transmitting signals across synapses.
  • SLUDGE syndrome: A collection of symptoms that result from exposure to certain drugs or toxins that stimulate the parasympathetic nervous system.

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