Oxycodone/naloxone

Oxycodone/Naloxone is a combination medication used to treat moderate to severe pain. It contains two active ingredients: Oxycodone, a semi-synthetic opioid analgesic, and Naloxone, an opioid antagonist. This combination is designed to provide pain relief (from Oxycodone) while reducing the risk of opioid-induced constipation (through Naloxone).

Mechanism of Action

Oxycodone works by binding to mu-opioid receptors in the brain, spinal cord, and other areas of the body. This binding action reduces the perception of pain. Naloxone, on the other hand, is an opioid antagonist that blocks the effects of opioids, including constipation. When taken orally, Naloxone has minimal systemic absorption and primarily acts on the mu-opioid receptors in the gut, reducing the constipating effects of Oxycodone.

Indications

Oxycodone/Naloxone is indicated for the management of pain severe enough to require daily, around-the-clock, long-term opioid treatment and for which alternative treatment options are inadequate. It is also used to manage opioid-induced constipation.

Side Effects

Common side effects of Oxycodone/Naloxone include nausea, vomiting, constipation, dizziness, and drowsiness. Serious side effects may include slowed breathing, addiction, and overdose.

Contraindications

Oxycodone/Naloxone is contraindicated in patients with significant respiratory depression, acute or severe bronchial asthma, known or suspected paralytic ileus, and hypersensitivity to Oxycodone or Naloxone.

See Also

• Opioid
• Pain Management
• Constipation

References

• Oxycodone/Naloxone Product Monograph
• Opioid Analgesics
• Opioid Antagonists

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Oxycodone/naloxone

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  Oxycodone

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  Naloxone