Ribosome

Ribosome

The Ribosome is a complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis (translation). Ribosomes link amino acids together in the order specified by messenger RNA (mRNA) molecules. Ribosomes consist of two major components: the small ribosomal subunits, which read the RNA, and the large subunits, which join amino acids to form a polypeptide chain. Each subunit consists of one or more ribosomal RNA (rRNA) molecules and a variety of ribosomal proteins (r-proteins).

Structure

Ribosomes are composed of two subunits that fit together and work as one to translate the mRNA into a polypeptide chain during protein synthesis. Because they are formed from two subunits of non-equal size, they are slightly longer in the axis than in diameter.

Prokaryotic Ribosomes

Prokaryotic ribosomes are around 20 nm (200 Å) in diameter and are composed of 65% rRNA and 35% ribosomal proteins. Because of their size, they are slightly smaller than eukaryotic ribosomes.

Eukaryotic Ribosomes

Eukaryotic ribosomes are between 25 and 30 nm (250–300 Å) in diameter with an rRNA to protein ratio that is close to 1. Eukaryotic ribosomes are larger than prokaryotic ribosomes, and their differences in size and composition are largely due to an increased protein content.

Function

The primary function of ribosomes is to synthesize proteins. Ribosomes do this by assembling amino acids into polypeptide chains. This process is known as translation.

See also

• Protein biosynthesis
• Messenger RNA
• Transfer RNA
• Translation (biology)

References

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Ribosome

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  Ribosome shape

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  Peptide synthesis

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  Ribosome structure

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  Small subunit 1FKA

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  Large subunit

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  Ribosome in action

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  Protein translation