Parafluorofuranylfentanyl

Parafluorofuranylfentanyl (PFF) is a potent opioid analgesic drug that is an analog of fentanyl. It is part of the fentanyl analogues and has been sold online as a designer drug.

Chemistry

Parafluorofuranylfentanyl is a full agonist at the mu-opioid receptor. It is structurally related to fentanyl, but differs by the addition of a para-fluoro group and a furanyl group.

Pharmacology

Like other opioids, parafluorofuranylfentanyl acts on the mu-opioid receptor to produce its analgesic effects. It is significantly more potent than fentanyl, with a potency approximately 5 times that of fentanyl. This increased potency is due to the addition of the para-fluoro group, which increases the lipophilicity of the molecule and enhances its penetration across the blood-brain barrier.

Effects

The effects of parafluorofuranylfentanyl are similar to those of other opioids and include analgesia, sedation, euphoria, and respiratory depression. Due to its high potency, the risk of overdose is significant, especially when it is used recreationally or without medical supervision. Overdose can result in severe respiratory depression, unconsciousness, and death.

Legal Status

Parafluorofuranylfentanyl is a controlled substance in many countries due to its potential for abuse and the risk of overdose. In the United States, it is a Schedule I controlled substance under the Controlled Substances Act.

See Also

• Fentanyl
• Opioid
• Designer drug
• Controlled Substances Act

References

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  Structure of Parafluorofuranylfentanyl