Pentolinium
Pentolinium
Pentolinium (pronunciation: pen-toh-lin-ee-uhm) is a pharmacological agent that belongs to the class of medication known as ganglionic blockers.
Etymology
The term "Pentolinium" is derived from the chemical structure of the drug, which consists of a pentamethylene bridge (five carbon atoms) connecting two quinuclidine rings.
Usage
Pentolinium is primarily used in the management of hypertension (high blood pressure). It works by blocking the transmission of nerve impulses in certain autonomic ganglia, which results in a decrease in blood pressure.
Related Terms
- Ganglionic blocker: A type of drug that inhibits the transmission of nerve impulses in autonomic ganglia.
- Hypertension: A medical condition characterized by high blood pressure.
- Quinuclidine: A nitrogen-containing heterocyclic compound that forms part of the structure of pentolinium.
Side Effects
Like all medications, pentolinium can cause side effects. These may include dizziness, nausea, dry mouth, and constipation. In rare cases, it can cause severe hypotension (low blood pressure).
Precautions
Pentolinium should be used with caution in patients with cardiac disease, renal impairment, or hepatic impairment. It should not be used in patients with myasthenia gravis, a neuromuscular disease that causes muscle weakness.
Interactions
Pentolinium may interact with other medications, including other antihypertensive drugs, anticholinergic drugs, and neuromuscular blocking agents.
External links
- Medical encyclopedia article on Pentolinium
- Wikipedia's article - Pentolinium
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