Pipecuronium bromide
Pipecuronium Bromide
Pipecuronium Bromide (pronounced as pipe-cu-ro-nium bro-mide) is a non-depolarizing neuromuscular-blocking drug or neuromuscular-blocking agent used in modern anaesthesia to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
Etymology
The term "Pipecuronium Bromide" is derived from the chemical structure of the drug. "Pipe-" refers to the piperidine ring structure, "-curonium" is a common suffix for non-depolarizing neuromuscular blockers, and "Bromide" refers to the bromine atom present in the molecule.
Pharmacology
Pipecuronium Bromide is a long-acting, non-depolarizing muscle relaxant. It competes with acetylcholine at the motor end-plate to inhibit neuromuscular transmission. This results in skeletal muscle relaxation and paralysis.
Clinical Use
Pipecuronium Bromide is used primarily to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is also used in the management of critically ill patients in the Intensive Care Unit (ICU).
Side Effects
Like other neuromuscular-blocking agents, Pipecuronium Bromide can cause a range of side effects, including hypotension, bradycardia, and anaphylaxis. It may also cause prolonged muscle paralysis and respiratory depression if not properly reversed.
Related Terms
- Neuromuscular-blocking drug
- Endotracheal intubation
- Anaesthesia
- Acetylcholine
- Motor end-plate
- Muscle relaxant
- Intensive Care Unit
- Hypotension
- Bradycardia
- Anaphylaxis
External links
- Medical encyclopedia article on Pipecuronium bromide
- Wikipedia's article - Pipecuronium bromide
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