Prorenin
Prorenin
Prorenin (/proʊˈrɛnɪn/) is a precursor to the enzyme renin, which is involved in the regulation of blood pressure and electrolyte balance in the body.
Etymology
The term "prorenin" is derived from the prefix "pro-", meaning "before", and "renin", referring to the enzyme that it precedes in the biosynthetic pathway.
Function
Prorenin is synthesized and stored in the juxtaglomerular cells of the kidney. In response to certain stimuli, such as low blood pressure or low sodium concentration, prorenin is converted into active renin. This conversion is facilitated by the enzyme prorenin converting enzyme.
Renin then acts on angiotensinogen, a protein produced by the liver, to produce angiotensin I. Angiotensin I is subsequently converted into angiotensin II by the action of angiotensin-converting enzyme (ACE). Angiotensin II is a potent vasoconstrictor, meaning it narrows the blood vessels and increases blood pressure.
Related Terms
- Renin: The active form of prorenin, involved in the regulation of blood pressure and electrolyte balance.
- Angiotensinogen: A protein that is acted upon by renin to produce angiotensin I.
- Angiotensin I: A peptide hormone that is converted into angiotensin II by ACE.
- Angiotensin II: A potent vasoconstrictor that increases blood pressure.
- Angiotensin-converting enzyme (ACE): An enzyme that converts angiotensin I into angiotensin II.
- Juxtaglomerular cells: Cells in the kidney that synthesize and store prorenin.
- Prorenin converting enzyme: An enzyme that facilitates the conversion of prorenin into renin.
External links
- Medical encyclopedia article on Prorenin
- Wikipedia's article - Prorenin
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