Pseudoallergy

Pseudoallergy
Synonyms	Non-allergic hypersensitivity
Pronounce	N/A
Specialty	N/A
Symptoms	Urticaria, angioedema, anaphylactoid reactions
Complications	N/A
Onset	Varies depending on exposure
Duration	Variable, often short-term
Types	N/A
Causes	Non-immunological activation of mast cells
Risks	Aspirin, NSAIDs, food additives
Diagnosis	Clinical evaluation, exclusion of IgE-mediated allergy
Differential diagnosis	True allergy, intolerance
Prevention	N/A
Treatment	Avoidance of triggers, antihistamines
Medication	N/A
Prognosis	N/A
Frequency	Common, varies by population
Deaths	N/A

Pseudoallergy is a type of hypersensitivity reaction that mimics an allergy, but is not caused by the immune system's response to an allergen. Instead, it is often caused by non-specific activation of certain immune system cells.

Causes

Pseudoallergies can be triggered by a variety of substances, including certain food additives, medications, and chemicals. Unlike true allergies, pseudoallergies do not involve the immune system's production of IgE antibodies, and they do not require prior exposure to the triggering substance.

Symptoms

The symptoms of a pseudoallergy can closely resemble those of a true allergy, and can include hives, itching, nasal congestion, and anaphylaxis. However, the onset of symptoms is typically more rapid in a pseudoallergy, often occurring within minutes of exposure to the triggering substance.

Diagnosis

Diagnosing a pseudoallergy can be challenging, as the symptoms closely resemble those of a true allergy. However, a key difference is that pseudoallergies do not show up on allergy tests, as they do not involve the production of IgE antibodies. Instead, diagnosis is typically based on a detailed medical history and the exclusion of other potential causes.

Treatment

Treatment for pseudoallergies typically involves avoiding the triggering substance. In some cases, medications such as antihistamines or corticosteroids may be used to manage symptoms. However, these treatments do not cure the pseudoallergy, and symptoms may recur if the individual is exposed to the triggering substance again.

See also

• Allergy
• Hypersensitivity
• Anaphylaxis
• Food additive
• Medication

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