Root sheath

General Information
Latin	vagina radicis
Greek
TA98
TA2
FMA
Details
System	Integumentary system
Artery	Dermal papilla
Vein
Nerve	Cutaneous nerve
Lymphatic drainage
Precursor
Function
Identifiers
Clinical significance
Notes

The root sheath is a critical component of the hair follicle structure, playing a vital role in the growth and development of hair. It is composed of two main layers: the inner root sheath (IRS) and the outer root sheath (ORS). These layers work together to support the hair shaft and facilitate its emergence through the skin.

Structure

Inner Root Sheath

The inner root sheath (IRS) is located closest to the hair shaft and is composed of three distinct layers:

• Henle's layer: The outermost layer of the IRS, consisting of a single layer of cuboidal cells.
• Huxley's layer: Situated between Henle's layer and the cuticle of the IRS, it is composed of several layers of flattened cells.
• Cuticle of the IRS: The innermost layer, which interlocks with the cuticle of the hair shaft, providing structural support and protection.

The IRS is responsible for shaping the hair shaft and guiding its growth through the follicle.

Outer Root Sheath

The outer root sheath (ORS) surrounds the IRS and extends from the base of the follicle to the epidermis. It is continuous with the epidermis and is composed of several layers of cells that provide structural integrity to the follicle. The ORS is also involved in the regeneration of the hair follicle during the hair growth cycle.

Function

The root sheath serves several important functions:

• Protection: It protects the developing hair shaft from physical and chemical damage.
• Support: Provides structural support to the hair follicle, ensuring the proper alignment and growth of the hair shaft.
• Regeneration: The ORS contains stem cells that are crucial for the regeneration of the hair follicle during the hair cycle.

Clinical Significance

The root sheath is involved in various dermatological conditions and treatments:

• Alopecia: Damage or dysfunction in the root sheath can lead to hair loss conditions such as alopecia areata.
• Hair Transplantation: Understanding the structure and function of the root sheath is essential for successful hair transplantation procedures.
• Folliculitis: Inflammation of the hair follicle, including the root sheath, can lead to conditions such as folliculitis.

Also see

• Hair follicle
• Hair cycle
• Alopecia
• Folliculitis
• Dermal papilla

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